Anti-SDCBP Polyclonal Antibody (HT180014)

Name: Anti-SDCBP Polyclonal Antibody
Brand: abinScience
SKU: HT180014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

HT180014

Description

Anti-SDCBP Polyclonal Antibody (HT180014) is a rabbit polyclonal antibody detecting SDCBP in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SDCBP (Ser2-Val298).

Target

Pro-TGF-alpha cytoplasmic domain-interacting protein 18, Melanoma differentiation-associated protein 9, SYCL, SDCBP, MDA9, MDA-9, Syntenin-1, Syndecan-binding protein 1, TACIP18, Scaffold protein Pbp1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

O00560

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Syntenin-1 (SDCBP) is a ~32 kDa protein. Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types.

1. Philley, JV. et al. (2016) Journal of cellular physiology 231, 545-50. PMID: 26291527

2. Hwangbo, C. et al. (2016) Oncogene 35, 389-401. PMID: 25893292

3. Baietti, MF. et al. (2012) Nature cell biology 14, 677-85. PMID: 22660413

4. Kashyap, R. et al. (2015) Frontiers in pharmacology 6, 241. PMID: 26539120

5. Geijsen, N. et al. (2001) Science (New York, N.Y.) 293, 1136-8. PMID: 11498591

6. Zimmermann, P. et al. (2001) Molecular biology of the cell 12, 339-50. PMID: 11179419

7. Fernández-Larrea, J. et al. (1999) Molecular cell 3, 423-33. PMID: 10230395

Note

For research use only.

Images

References

Datasheet

Anti-SDCBP Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-SDCBP Polyclonal Antibody (HT180014)

Overview

Images

References

Datasheet

SDS

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