Anti-SLC19A1 Polyclonal Antibody (HW317014)

Name: Anti-SLC19A1 Polyclonal Antibody
Brand: abinScience
SKU: HW317014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HW317014

Description

Anti-SLC19A1 Polyclonal Antibody (HW317014) is a rabbit polyclonal antibody detecting SLC19A1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human SLC19A1 (Leu455-Gln591).

Target

Intestinal folate carrier 1, FOLT, Solute carrier family 19 member 1, RFC1, hSLC19A1, IFC-1, SLC19A1, RFT-1, FLOT1, RFC, Placental folate transporter, Reduced folate transporter 1, Reduced folate transporter, Reduced folate carrier protein, hRFC

Purification

Purified by antigen affinity column.

Accession

P41440

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Reduced folate transporter (SLC19A1) is a ~64 kDa protein. Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions. Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses. Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also mediates the import of antifolate drug methotrexate.

1. Chancy, CD. et al. (2000) The Journal of biological chemistry 275, 20676-84. PMID: 10787414

2. Witt, TL. et al. (2004) The Journal of biological chemistry 279, 46755-63. PMID: 15337749

3. Hou, Z. et al. (2005) The Journal of biological chemistry 280, 36206-13. PMID: 16115875

4. Visentin, M. et al. (2012) Molecular pharmacology 82, 209-16. PMID: 22554803

5. Ritchie, C. et al. (2019) Molecular cell 75, 372-381.e5. PMID: 31126740

6. Luteijn, RD. et al. (2019) Nature 573, 434-438. PMID: 31511694

7. Svaton, M. et al. (2020) Blood 135, 2427-2431. PMID: 32276275

8. Wright, NJ. et al. (2022) Nature 609, 1056-1062. PMID: 36071163

9. Zhang, Q. et al. (2022) Nature 612, 170-176. PMID: 36265513

10. Dang, Y. et al. (2022) Cell discovery 8, 141. PMID: 36575193

Note

For research use only.

Images

References

Datasheet

Anti-SLC19A1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-SLC19A1 Polyclonal Antibody (HW317014)

Overview

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References

Datasheet

SDS

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