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Anti-SOCS2 Polyclonal Antibody (HT326014)

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Overview
Catalog No.HT326014
Description
Anti-SOCS2 Polyclonal Antibody (HT326014) is a rabbit polyclonal antibody detecting SOCS2 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, Rat, and Pig.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human SOCS2 (Met1-Val198).
Target CIS-2, STAT-induced STAT inhibitor 2, SSI-2, SOCS2, STATI2, CIS2, Cytokine-inducible SH2 protein 2, SSI2, Suppressor of cytokine signaling 2, SOCS-2
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession O14508
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Suppressor of cytokine signaling 2 (SOCS2) is a ~22 kDa protein. Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR.

1. Eyckerman, S. et al. (2001) Nature cell biology 3, 1114-9. PMID: 11781573
2. Vesterlund, M. et al. (2011) PloS one 6, e25358. PMID: 21980433
3. Bulatov, E. et al. (2015) The Journal of biological chemistry 290, 4178-91. PMID: 25505247
4. Kung, WW. et al. (2019) Nature communications 10, 2534. PMID: 31182716
5. Linossi, EM. et al. (2021) Nature communications 12, 7032. PMID: 34857742
6. Ramachandran, S. et al. (2023) Nature communications 14, 6345. PMID: 37816714
Note For research use only.
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Datasheet
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Formula
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Anti-SOCS2 Polyclonal Antibody

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