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Anti-SUV39H1 Polyclonal Antibody (HT471014)

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Overview
Catalog No.HT471014
Description
Anti-SUV39H1 Polyclonal Antibody (HT471014) is a rabbit polyclonal antibody detecting SUV39H1 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Pongo abelii.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human SUV39H1 (Gly7-Met271).
Target Position-effect variegation 3-9 homolog, SUV39H, H3-K9-HMTase 1, SUV39H1, Histone-lysine N-methyltransferase SUV39H1, Su(var)3-9 homolog 1, Lysine N-methyltransferase 1A, Histone H3-K9 methyltransferase 1, Suppressor of variegation 3-9 homolog 1, KMT1A
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession O43463
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Histone-lysine N-methyltransferase SUV39H1 is a ~47 kDa protein. Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats.

1. Rea, S. et al. (2000) Nature 406, 593-9. PMID: 10949293
2. Lachner, M. et al. (2001) Nature 410, 116-20. PMID: 11242053
3. Vaquero, A. et al. (2007) Nature 450, 440-4. PMID: 18004385
4. Zhou, L. et al. (2025) Science (New York, N.Y.) 389, 309-316. PMID: 40440427
5. Nielsen, SJ. et al. (2001) Nature 412, 561-5. PMID: 11484059
6. Ait-Si-Ali, S. et al. (2004) The EMBO journal 23, 605-15. PMID: 14765126
Note For research use only.
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Formula
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Anti-SUV39H1 Polyclonal Antibody

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