Anti-SYK Polyclonal Antibody (HW747014)

Name: Anti-SYK Polyclonal Antibody
Brand: abinScience
SKU: HW747014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HW747014

Description

Anti-SYK Polyclonal Antibody (HW747014) is a rabbit polyclonal antibody detecting SYK in ELISA, IHC, WB. Suitable for Human, Mouse, Pig, Rat, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant human SYK (Asp374-Asn635).

Target

Tyrosine-protein kinase SYK, EC:2.7.10.2, Spleen tyrosine kinase, p72-Syk, SYK

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P43405, P48025, Q00655, Q64725, F1N9Y5

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Tyrosine-protein kinase SYK is a ~72 kDa protein. Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor.

1. Urzainqui, A. et al. (2002) Immunity 17, 401-12. PMID: 12387735

2. Wang, L. et al. (2021) Nature genetics 53, 500-510. PMID: 33782605

3. Chiu, CW. et al. (2002) The EMBO journal 21, 6461-72. PMID: 12456653

4. Shim, EK. et al. (2004) FEBS letters 575, 35-40. PMID: 15388330

5. M Gagné, L. et al. (2021) The Journal of biological chemistry 297, 101291. PMID: 34634301

6. Law, CL. et al. (1996) Molecular and cellular biology 16, 1305-15. PMID: 8657103

7. Ratthé, C. et al. (2004) Journal of leukocyte biology 76, 162-8. PMID: 15123770

Note

For research use only

Images

References

Datasheet

Anti-SYK Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-SYK Polyclonal Antibody (HW747014)

Overview

Images

References

Datasheet

SDS