Anti-TACR2 Polyclonal Antibody (HB728014)

Name: Anti-TACR2 Polyclonal Antibody
Brand: abinScience
SKU: HB728014
Price: 96 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HB728014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TACR2 (Asn311-Ser366).

Target

NK-2 receptor, NKNAR, Neurokinin A receptor, SKR, Tachykinin receptor 2, TACR2, TAC2R, Substance-K receptor, NK2R, NK-2R

Purification

Purified by antigen affinity column.

Accession

P21452

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Substance-K receptor (TACR2) is a ~44 kDa protein. This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). Is also able to bind and respond to tachynins substance P and neurokinin B/neuromedin-K. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. Substance K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C. Substance K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP).

1. Cyr, C. et al. (1991) Annals of the New York Academy of Sciences 632, 426-7. PMID: 1659297

2. Kris, RM. et al. (1991) Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2, 15-22. PMID: 1848773

3. Edgerton, MD. et al. (1994) FEBS letters 354, 195-9. PMID: 7957923

4. Sun, W. et al. (2022) Cell discovery 8, 72. PMID: 35882833

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-TACR2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse heart lysate
Lane 2: Mouse lung lysate
Lane 3: Mouse brain lysate
Lane 4: Rat heart lysate
Lane 5: Rat brain lysate
Western blot

Western blot analysis was performed using anti-TACR2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse stomach lysate