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Anti-Tau (phosphe T217) Recombinant Antibody (SAA2786) (HY086263)

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Overview

Catalog No.	HY086263
Description	Anti-Tau (phosphe T217) Antibody (SAA2786) (HY086263) is a rabbit monoclonal antibody detecting TAU. Suitable for Human.
Species reactivity	Homo sapiens (Human)
Applications	ELISA, DB, IF
Host species	Rabbit
Isotype	IgG
Clone ID	SAA2786
Clonality	Monoclonal
Target	MAPT, MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau, TAU
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P10636
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Microtubule-associated protein tau (Tau pT217) is a ~78 kDa protein. Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. 1. Yoshida, H. et al. (2012) Journal of neurochemistry 120, 165-76. PMID: 21985311 2. Sandberg, A. et al. (2020) Neurobiology of disease 146, 105079. PMID: 32961270
Note	For research use only

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Datasheet

Anti-Tau (phosphe T217) Recombinant Antibody (SAA2786).pdf

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Anti-Tau (phosphe T217) Recombinant Antibody (SAA2786)