Anti-TH Polyclonal Antibody (HY108014)

Name: Anti-TH Polyclonal Antibody
Brand: abinScience
SKU: HY108014
Price: 96 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HY108014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human TH (Met1-Ile260).

Target

Tyrosine 3-hydroxylase, TYH, Tyrosine 3-monooxygenase, TH

Purification

Purified by antigen affinity column.

Accession

P07101

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Tyrosine 3-monooxygenase (TH) is a ~58 kDa protein. Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity. Positively regulates the regression of retinal hyaloid vessels during postnatal development.

1. Sura, GR. et al. (2004) Journal of neurochemistry 90, 970-8. PMID: 15287903

2. Le Bourdellès, B. et al. (1991) The Journal of biological chemistry 266, 17124-30. PMID: 1680128

3. Roma, J. et al. (2007) Biological chemistry 388, 419-26. PMID: 17391063

4. Fossbakk, A. et al. (2014) Human mutation 35, 880-90. PMID: 24753243

5. Inukai, S. et al. (2022) Biochemical and biophysical research communications 589, 209-214. PMID: 34922205

6. Knappskog, PM. et al. (1995) Human molecular genetics 4, 1209-12. PMID: 8528210

Note

For research use only.

Images

References

Datasheet

Anti-TH Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-TH Polyclonal Antibody (HY108014)

Overview

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References

Datasheet

SDS

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