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Anti-TPPP Polyclonal Antibody (HF892014)

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Overview
Catalog No.HF892014
Description
Anti-TPPP Polyclonal Antibody (HF892014) is a rabbit polyclonal antibody detecting TPPP in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human TPPP (Ala8-Thr210).
Target 25 kDa brain-specific protein, TPPP/p25, Tubulin polymerization-promoting protein, p24, p25-alpha, TPPP, TPPP1
Purification Purified by antigen affinity column.
Accession O94811
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Tubulin polymerization-promoting protein (TPPP) is a ~23 kDa protein. Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath. Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes. Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear. In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network.

1. Fu, MM. et al. (2019) Cell 179, 132-146.e14. PMID: 31522887
2. Doi, S. et al. (2021) Cell calcium 96, 102404. PMID: 33831707
3. Zotter, A. et al. (2011) FEBS letters 585, 803-8. PMID: 21316364
4. Zotter, Á. et al. (2011) Biochemistry 50, 9568-78. PMID: 21995432
5. Vincze, O. et al. (2006) Biochemistry 45, 13818-26. PMID: 17105200
6. Hlavanda, E. et al. (2007) The Journal of biological chemistry 282, 29531-9. PMID: 17693641
7. Acevedo, K. et al. (2007) Experimental cell research 313, 4091-106. PMID: 18028908
8. DeBonis, S. et al. (2015) Scientific reports 5, 13242. PMID: 26289831
9. Tokési, N. et al. (2010) The Journal of biological chemistry 285, 17896-906. PMID: 20308065
Note For research use only.
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Datasheet
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Formula
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Anti-TPPP Polyclonal Antibody

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