

| Catalog No. | HV439014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human TRPV3 (Asn671-Val790). | ||||||||
| Target | TrpV3, Vanilloid receptor-like 3, Transient receptor potential cation channel subfamily V member 3, VRL-3, TRPV3 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q8NET8 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Transient receptor potential cation channel subfamily V member 3 (TRPV3) is a ~90 kDa protein. Non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. The channel pore can dilate to provide permeability to larger cations. May associate with TRPV1 and may modulate its activity. 1. Xu, H. et al. (2002) Nature 418, 181-6. PMID: 12077604 2. Smith, GD. et al. (2002) Nature 418, 186-90. PMID: 12077606 3. Li, C. et al. (2016) Traffic (Copenhagen, Denmark) 17, 500-14. PMID: 26818531 4. Lansky, S. et al. (2023) Nature 621, 206-214. PMID: 37648856 5. Nadezhdin, KD. et al. (2024) Science advances 10, eadn2453. PMID: 38691614 | ||||||||
| Note | For research use only. |
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