Anti-ZEBOV GP/Envelope glycoprotein Recombinant Antibody (mAb100) (VK623023)

Name: Anti-ZEBOV GP/Envelope glycoprotein Recombinant Antibody (mAb100)
Brand: abinScience
SKU: VK623023
Price: 126 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

VK623023

Species reactivity

Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus), Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus)

Applications

ELISA

Host species

Human

Isotype

IgG

Clone ID

mAb100

Clonality

Monoclonal

Target

GP, Envelope glycoprotein

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P87666, Q05320

RRID

Anti-ZEBOV GP/Envelope glycoprotein Antibody (mAb100) (abinScience Cat# VK623023, RRID:AB_3727244)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Envelope glycoprotein (GP) is a ~74 kDa protein. Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, down-regulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes.

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-ZEBOV GP/Envelope glycoprotein Antibody (mAb100)

References

Datasheet

Anti-ZEBOV GP/Envelope glycoprotein Recombinant Antibody (mAb100).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-ZEBOV GP/Envelope glycoprotein Recombinant Antibody (mAb100) (VK623023)

Overview

Images

References

Datasheet

SDS

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