

| Catalog No. | VK783014 | ||||
|---|---|---|---|---|---|
| Description |
Anti-ZEBOV VP40 Polyclonal Antibody (VK783014) is a rabbit polyclonal antibody detecting VP40 in ELISA, IHC, WB. Suitable for Zaire ebolavirus.
Highlights
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| Species reactivity | Zaire ebolavirus | ||||
| Applications | ELISA, IHC, WB | ||||
| Host species | Rabbit | ||||
| Isotype | IgG | ||||
| Clonality | Polyclonal | ||||
| Immunogen | E. coli - derived recombinant ZEBOV VP40 (Asn31-Lys326). | ||||
| Target | Matrix protein VP40, Ebola VP40, eVP40, Membrane-associated protein VP40, VP40 | ||||
| Endotoxin level | Please contact with the lab for this information. | ||||
| Purification | Purified by antigen affinity column. | ||||
| Accession | Q77DJ6, Q05128, Q2PDK5 | ||||
| Form | Liquid | ||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Background | Matrix protein VP40 is a ~35 kDa protein. Plays an essential role virus particle assembly and budding. Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD6IP/ALIX, NEDD4 or TGS101. The interaction with host E3 ubiquitin ligase SMURF2 also facilitates virus budding. May play a role in immune cell dysfunction by being packaged into exosomes that can decrease the viability of recipient cells (via RNAi suppression and exosome-bystander apoptosis). | ||||
| Note | For research use only |
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