| Target |
Capsid protein, Capsid protein C, Core protein, EC:2.1.1.56, EC:2.1.1.57, EC:2.7.7.48, EC:3.4.21.91, EC:3.6.1.15, EC:3.6.4.13, Envelope protein E, Flavivirin protease NS2B regulatory subunit, Flavivirin protease NS3 catalytic subunit, Genome polyprotein, Matrix protein, NS1, NS2A, NS4A, NS4B, NS5, Non-structural protein 1, Non-structural protein 2A, Non-structural protein 2B, Non-structural protein 3, Non-structural protein 4A, Non-structural protein 4B, Peptide 2k, Peptide pr, Peptide precursor, Precursor membrane protein, Protein prM, RNA-directed RNA polymerase/Methyltransferase NS5, Serine protease NS3, Serine protease subunit NS2B, Small envelope protein M |
| Background | Initiator protein NS1 is a ~74 kDa protein. Multifunctional protein essential for viral DNA replication, which cooperatively interacts with the viral DNA origin of replication and transactivates several promoters including the viral p6 promoter. Binds the origin of replication and performs an endonucleolytic nick within a conserved sequence in the viral genome, thereby initiating the rolling circle replication (RCR). Participates in the transcriptional regulation the viral p6 promoter that regulates all viral transcripts and the cellular CDN1A or IL6 promoters. Transactivates several host promoters some of which induce the S cell cycle phase for the production of host replicative proteins. Up-regulates the expression of host E2F4 and E2F5 and interacts with both these factors thereby inhibiting the host cell cycle G2/M transition. |
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