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InVivo Plus Mouse CD8 alpha Antibody(2.43) (MF815109)

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InVivo Plus Mouse CD8 alpha Antibody(2.43)

InVivo Plus Mouse CD8 alpha Antibody(2.43)

InVivo Plus Mouse CD8 alpha Antibody(2.43)

InVivo Plus Mouse CD8 alpha Antibody(2.43)

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SDS

Overview

Catalog No.	MF815109
Description	InVivo Plus Anti-Mouse CD8a/Lyt2 Antibody (2.43) [2.43] (MF815109) is a rat monoclonal antibody detecting T-cell surface glycoprotein CD8 alpha chain in FCM, in vivo CD8+ T cell depletion, Western blot, Neutralization. Suitable for Mouse. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Mouse
Applications	FCM, in vivo CD8+ T cell depletion, Western blot, Neutralization
Host species	Rat
Isotype	lgG2b
Clone ID	2.43
Clonality	Monoclonal
Target	T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein Lyt-2, CD8a, Cd8a, Lyt-2, Lyt2, cd8
Endotoxin level	<1 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P01731
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	T-cell surface glycoprotein CD8 alpha chain (CD8a/Lyt2) is a ~27 kDa protein. Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.
Note	For research use only.

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SDS-PAGE

SDS-PAGE for InVivo Plus Anti-Mouse CD8a/Lyt2 Antibody (2.43)
Bioactivity

Detects CD8a/Lyt2 (Catalog No. MF815011) in indirect ELISAs.

References

Datasheet

InVivo Plus Mouse CD8 alpha Antibody(2.43).pdf

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InVivo Plus Mouse CD8 alpha Antibody(2.43)