InVivoMAb Anti-Human CD37 Antibody (Iv0275) (HY564010)

Name: InVivoMAb Anti-Human CD37 Antibody (Iv0275)
Brand: abinScience
SKU: HY564010
Price: 370 USD
Availability: InStock

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100ug
1mg

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Overview

Catalog No.	HY564010
Description	InVivoMAb Anti-Human CD37/TSPAN26 Antibody (Iv0275) [Iv0275] (HY564010) is a human monoclonal antibody detecting CD37 in ELISA, FCM, Neutralization, WB. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human
Applications	ELISA, FCM, Neutralization, WB
Host species	Human
Isotype	IgG1, kappa
Clone ID	Iv0275
Clonality	Monoclonal
Target	CD37, Tspan-26, TSPAN26, Leukocyte antigen CD37, Tetraspanin-26
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Associated products	pH 7.4 Dilution Buffer
Purification	Protein A/G purified from cell culture supernatant.
Accession	P11049
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Leukocyte antigen CD37 (TSPAN26) is a ~31 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B. Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT. 1. Lapalombella, R. et al. (2012) Cancer cell 21, 694-708. PMID: 22624718 2. de Winde, CM. et al. (2016) The Journal of clinical investigation 126, 653-66. PMID: 26784544 3. Meyer-Wentrup, F. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 178, 154-62. PMID: 17182550
Note	For research use only. Not suitable for clinical or therapeutic use.