Canine Beta-NGF Recombinant Protein (C-Fc) (CF909021)

Name: Canine Beta-NGF Recombinant Protein (C-Fc)
Brand: abinScience
SKU: CF909021
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	CF909021
Description	Recombinant Dog NGF/Beta-NGF Protein, C-Fc (CF909021) expressed in Mammalian Cells, spanning Ser122-Ala241. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	F1PDQ3
Protein length	Ser122-Ala241
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Canis lupus familiaris (Dog) (Canis familiaris)
Nature	Recombinant
Target	Beta-NGF, Beta-nerve growth factor, NGF, NGFB
Endotoxin level	<0.1 EU/ug as determined by LAL method.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	41.76 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Beta-NGF, Beta-nerve growth factor, NGF, NGFB
Background	Beta-nerve growth factor (Beta-nerve growth factor,NGFB,Beta-NGF,NGF) is a ~26 kDa protein. Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. 1. Einarsdottir, E. et al. (2004) Human molecular genetics 13, 799-805. PMID: 14976160 2. Carvalho, OP. et al. (2011) Journal of medical genetics 48, 131-5. PMID: 20978020 3. Wijeyewickrema, LC. et al. (2010) The Journal of biological chemistry 285, 11793-9. PMID: 20164177
Note	For research use only

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References

Datasheet

Canine Beta-NGF Recombinant Protein (C-Fc).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Formula

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Stock Solution

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Recombinant Proteins

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Canine Beta-NGF Recombinant Protein (C-Fc) (CF909021)

Overview

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References

Datasheet

SDS