Human AARS2 Recombinant Protein (N-His) (HD871012)

Name: Human AARS2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD871012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD871012
Description	Recombinant Human AARS2 Protein, N-His (HD871012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q5JTZ9
Protein length	Gly24-Ala484
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	AARS2, AARSL, AlaRS, Alanine--tRNA ligase, mitochondrial, Alanyl-tRNA synthetase, EC:6.-.-.-, EC:6.1.1.7, KIAA1270, Protein lactyltransferase AARS2
Background	Alanine--tRNA ligase, mitochondrial is a ~107 kDa protein. Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as CGAS. Acts as an inhibitor of cGAS/STING signaling by catalyzing lactylation of CGAS, preventing the formation of liquid-like droplets in which CGAS is activated. 1. Götz, A. et al. (2011) American journal of human genetics 88, 635-42. PMID: 21549344 2. Li, H. et al. (2024) Nature 634, 1229-1237. PMID: 39322678
Note	For research use only

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Human AARS2 Recombinant Protein (N-His).pdf

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Human AARS2 Recombinant Protein (N-His) (HD871012)

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