Human ABCC1 Recombinant Protein (N-His) (HW501012)

Name: Human ABCC1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HW501012
Price: 211 USD
Availability: InStock

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Catalog No.	HW501012
Description	Recombinant Human ABCC1 Protein, N-His (HW501012) expressed in E. coli, spanning Glu848-Met967. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P33527
Protein length	Glu848-Met967
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	15.61 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ABCC1, ATP-binding cassette sub-family C member 1, EC:7.6.2.2, EC:7.6.2.3, Glutathione-S-conjugate-translocating ATPase ABCC1, LTC4 transporter, Leukotriene C(4) transporter, MRP, MRP1, Multidrug resistance-associated protein 1
Background	Multidrug resistance-associated protein 1 is a ~171 kDa protein. Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. 1. Sjölinder, M. et al. (1999) Journal of lipid research 40, 439-46. PMID: 10064732 2. Robbiani, DF. et al. (2000) Cell 103, 757-68. PMID: 11114332 3. Conseil, G. et al. (2006) The Journal of biological chemistry 281, 43-50. PMID: 16230346 4. Leier, I. et al. (1994) The Journal of biological chemistry 269, 27807-10. PMID: 7961706 5. Stride, BD. et al. (1997) Molecular pharmacology 52, 344-53. PMID: 9281595
Note	For research use only

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Datasheet

Human ABCC1 Recombinant Protein (N-His).pdf

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Human ABCC1 Recombinant Protein (N-His) (HW501012)

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