Human ACOD1 Recombinant Protein (N-His) (HC834012)

Name: Human ACOD1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC834012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC834012
Description	Recombinant Human ACOD1 Protein, N-His (HC834012) expressed in E. coli, spanning Met1-Ser481. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	A6NK06
Protein length	Met1-Ser481
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	54.65 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ACOD1, Aconitate decarboxylase, Aconitate decarboxylase 1, CAD, Cis-aconitate decarboxylase, Cis-aconitic acid decarboxylase, EC:4.1.1.6, IRG1, Immune-responsive gene 1 protein
Background	Cis-aconitate decarboxylase is a ~52 kDa protein. Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation. 1. Li, Y. et al. (2013) The Journal of biological chemistry 288, 16225-16234. PMID: 23609450 2. Michelucci, A. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 7820-5. PMID: 23610393 3. Chen, F. et al. (2019) Proceedings of the National Academy of Sciences of the United States of America 116, 20644-20654. PMID: 31548418 4. Zhang, Z. et al. (2022) Molecular cell 82, 2844-2857.e10. PMID: 35662396
Note	For research use only

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Datasheet

Human ACOD1 Recombinant Protein (N-His).pdf

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Human ACOD1 Recombinant Protein (N-His) (HC834012)

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