Human ADCYAP1R1 Recombinant Protein (N-His-SUMO) (HW609012)

Name: Human ADCYAP1R1 Recombinant Protein (N-His-SUMO)
Brand: abinScience
SKU: HW609012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HW609012
Description	Recombinant Human ADCYAP1R1 Protein, N-His-SUMO (HW609012) expressed in E. coli, spanning Ser23-Leu156. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P41586
Protein length	Ser23-Leu156
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	27.47 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ADCYAP1R1, PAC1 receptor, PAC1R, PACAP type I receptor, PACAP-R-1, PACAP-R1, Pituitary adenylate cyclase-activating polypeptide type I receptor
Background	Pituitary adenylate cyclase-activating polypeptide type I receptor is a ~53 kDa protein. G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. 1. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270 2. Hu, E. et al. (2021) Journal of medicinal chemistry 64, 3427-3438. PMID: 33715378 3. Xu, Y. et al. (2022) Nature communications 13, 2272. PMID: 35477937 4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145
Note	For research use only