Human ADRA1B Recombinant Protein (N-His-SUMO) (HC753012)

Name: Human ADRA1B Recombinant Protein (N-His-SUMO)
Brand: abinScience
SKU: HC753012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC753012
Description	Recombinant Human ADRA1B Protein, N-His-SUMO (HC753012) expressed in E. coli, spanning Arg225-Thr295. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P35368
Protein length	Arg225-Thr295
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	20.42 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ADRA1B, Alpha-1B adrenergic receptor, Alpha-1B adrenoceptor, Alpha-1B adrenoreceptor
Background	Alpha-1B adrenergic receptor is a ~56 kDa protein. Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1B binds the catecholamine ligands norepinephrine and epinephrine. Can also couple to G(14) and G(16) proteins. Nuclear ADRA1B forms heterooligomers with ADRA1A to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. 1. Schwinn, DA. et al. (1995) The Journal of pharmacology and experimental therapeutics 272, 134-42. PMID: 7815325 2. Forray, C. et al. (1994) Molecular pharmacology 45, 703-8. PMID: 8183249 3. Wright, CD. et al. (2008) Circulation research 103, 992-1000. PMID: 18802028 4. Wright, CD. et al. (2012) Cellular signalling 24, 794-802. PMID: 22120526 5. Ogata, T. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 3811-6. PMID: 24567387
Note	For research use only

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Datasheet

Human ADRA1B Recombinant Protein (N-His-SUMO).pdf

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Human ADRA1B Recombinant Protein (N-His-SUMO) (HC753012)

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