Human ADRA2B Recombinant Protein (N-His) (HC824012)

Name: Human ADRA2B Recombinant Protein (N-His)
Brand: abinScience
SKU: HC824012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC824012
Description	Recombinant Human ADRA2B Protein, N-His (HC824012) expressed in E. coli, spanning Arg194-Arg368. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P18089
Protein length	Arg194-Arg368
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	20.88 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ADRA2B, ADRA2L1, ADRA2RL1, Alpha-2 adrenergic receptor subtype C2, Alpha-2B adrenergic receptor, Alpha-2B adrenoceptor, Alpha-2B adrenoreceptor, Alpha-2BAR
Background	Alpha-2B adrenergic receptor is a ~49 kDa protein. Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release. The rank order of potency for agonists of ADRA2B is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. 1. Small, KM. et al. (2001) The Journal of biological chemistry 276, 4917-22. PMID: 11056163 2. Lomasney, JW. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 5094-8. PMID: 2164221 3. Weinshank, RL. et al. (1990) Molecular pharmacology 38, 681-8. PMID: 2172775 4. Li, C. et al. (2012) The Journal of biological chemistry 287, 42784-94. PMID: 23105096 5. Zhang, M. et al. (2016) Molecular and cellular biology 36, 1152-63. PMID: 26811329
Note	For research use only

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Datasheet

Human ADRA2B Recombinant Protein (N-His).pdf

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Human ADRA2B Recombinant Protein (N-His) (HC824012)

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