Human AMH Recombinant Protein (N-His) (HY076022)

Name: Human AMH Recombinant Protein (N-His)
Brand: abinScience
SKU: HY076022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HY076022
Description	Recombinant Human AMH Protein, N-His (HY076022) expressed in E. coli, spanning Ala453-Arg560. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P03971
Protein length	Ala453-Arg560
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	13.88 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	AMH, Anti-Muellerian hormone, MIF, MIS, Muellerian-inhibiting factor, Muellerian-inhibiting substance
Background	Anti-Muellerian hormone is a ~59 kDa protein. The anti-Muellerian hormone (AMH) plays an important role in several reproductive functions. Anti-Muellerian hormone binds and activates AMHR2, its specific type-II receptor, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A) to regulate target gene expression through downstream SMAD protein signal transduction. Produced and secreted by Sertoli cells of the male fetus, anti-Muellerian hormone induces Muellerian duct regression during male fetal sexual differentiation. In female, it is produced by granulosa cells of the preantral and small antral follicles and acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. Also plays a role in Leydig cell differentiation and function. 1. Weenen, C. et al. (2004) Molecular human reproduction 10, 77-83. PMID: 14742691 2. Hart, KN. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34155118 3. Cate, RL. et al. (1986) Cell 45, 685-98. PMID: 3754790 4. Wilson, CA. et al. (1993) Molecular endocrinology (Baltimore, Md.) 7, 247-57. PMID: 8469238 5. di Clemente, N. et al. (2010) Molecular endocrinology (Baltimore, Md.) 24, 2193-206. PMID: 20861221
Note	For research use only