Human ANK3 Recombinant Protein (N-His) (HC518012)

Name: Human ANK3 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC518012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC518012
Description	Recombinant Human ANK3 Protein, N-His (HC518012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q12955
Protein length	Val1273-Glu1407
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ANK-3, ANK3, Ankyrin-3, Ankyrin-G
Background	Ankyrin-3 is a ~480 kDa protein. Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for costamere localization of DMD and betaDAG1. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption. Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions. 1. Kordeli, E. et al. (1995) The Journal of biological chemistry 270, 2352-9. PMID: 7836469 2. San-Cristobal, P. et al. (2014) Kidney international 85, 94-102. PMID: 23903368
Note	For research use only

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Datasheet

Human ANK3 Recombinant Protein (N-His).pdf

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Human ANK3 Recombinant Protein (N-His) (HC518012)

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