Human ATG9A Recombinant Protein (N-His) (HD739012)

Name: Human ATG9A Recombinant Protein (N-His)
Brand: abinScience
SKU: HD739012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD739012
Description	Recombinant Human ATG9A Protein, N-His (HD739012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q7Z3C6
Protein length	Cys155-Pro371
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	APG9-like 1, APG9L1, ATG9A, Autophagy-related protein 9A, mATG9
Background	Autophagy-related protein 9A is a ~94 kDa protein. Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1. In addition to autophagy, also plays a role in necrotic cell death. 1. Orsi, A. et al. (2012) Molecular biology of the cell 23, 1860-73. PMID: 22456507 2. Karanasios, E. et al. (2016) Nature communications 7, 12420. PMID: 27510922 3. Søreng, K. et al. (2018) EMBO reports 19. PMID: 29437695 4. Antón, Z. et al. (2020) Journal of cell science 133. PMID: 32513819 5. Guardia, CM. et al. (2020) Cell reports 31, 107837. PMID: 32610138 6. Maeda, S. et al. (2020) Nature structural & molecular biology 27, 1194-1201. PMID: 33106659 7. Ravussin, A. et al. (2021) Journal of cell science 134. PMID: 33468622 8. Ghanbarpour, A. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 33850023 9. Young, AR. et al. (2006) Journal of cell science 119, 3888-900. PMID: 16940348 10. Judith, D. et al. (2019) The Journal of cell biology 218, 1634-1652. PMID: 30917996
Note	For research use only

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Datasheet

Human ATG9A Recombinant Protein (N-His).pdf

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Human ATG9A Recombinant Protein (N-His) (HD739012)

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