Human ATL1 Recombinant Protein (N-His) (HD825012)

Name: Human ATL1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD825012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD825012
Description	Recombinant Human ATL1 Protein, N-His (HD825012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q8WXF7
Protein length	Gly33-Gly338
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ATL-1, ATL1, Atlastin-1, Brain-specific GTP-binding protein, EC:3.6.5.-, GBP-3, GBP3, GTP-binding protein 3, Guanine nucleotide-binding protein 3, SPG3, SPG3A, Spastic paraplegia 3 protein A, hGBP3
Background	Atlastin-1 is a ~63 kDa protein. Atlastin-1 (ATL1) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect. Two atlastin-1 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). 1. Zhu, PP. et al. (2003) The Journal of biological chemistry 278, 49063-71. PMID: 14506257 2. Rismanchi, N. et al. (2008) Human molecular genetics 17, 1591-604. PMID: 18270207 3. Hu, J. et al. (2009) Cell 138, 549-61. PMID: 19665976 4. Wang, S. et al. (2016) eLife 5. PMID: 27619977 5. Crosby, D. et al. (2022) The Journal of cell biology 221. PMID: 34817557 6. Shi, L. et al. (2024) Nature communications 15, 2488. PMID: 38509071 7. Byrnes, LJ. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2216-21. PMID: 21220294 8. Bian, X. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 3976-81. PMID: 21368113 9. Byrnes, LJ. et al. (2013) The EMBO journal 32, 369-84. PMID: 23334294
Note	For research use only

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Human ATL1 Recombinant Protein (N-His).pdf

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Human ATL1 Recombinant Protein (N-His) (HD825012)

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