Human CALCOCO2 Recombinant Protein (N-His) (HC772012)

Name: Human CALCOCO2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC772012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC772012
Description	Recombinant Human CALCOCO2 Protein, N-His (HC772012) expressed in E. coli, spanning Ser21-Ser120. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q13137
Protein length	Ser21-Ser120
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	14.28 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Antigen nuclear dot 52 kDa protein, CALCOCO2, Calcium-binding and coiled-coil domain-containing protein 2, NDP52, Nuclear domain 10 protein 52, Nuclear domain 10 protein NDP52, Nuclear dot protein 52
Background	Calcium-binding and coiled-coil domain-containing protein 2 is a ~52 kDa protein. Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion. 1. Thurston, TL. et al. (2012) Nature 482, 414-8. PMID: 22246324 2. von Muhlinen, N. et al. (2012) Molecular cell 48, 329-42. PMID: 23022382 3. Verlhac, P. et al. (2015) Cell host & microbe 17, 515-25. PMID: 25771791 4. Morriswood, B. et al. (2007) Journal of cell science 120, 2574-85. PMID: 17635994
Note	For research use only

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Datasheet

Human CALCOCO2 Recombinant Protein (N-His).pdf

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Human CALCOCO2 Recombinant Protein (N-His) (HC772012)

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