

| Catalog No. | HD918012 |
|---|---|
| Description |
Recombinant Human CAMSAP2 Protein, N-His (HD918012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Expression system | E. coli |
| Accession | Q08AD1 |
| Protein length | Asp26-Lys338 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Species | Homo sapiens (Human) |
| Nature | Recombinant |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >90% as determined by SDS-PAGE. |
| Form | Lyophilized |
| Storage buffer | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Shipping | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Alternate Names | CAMSAP1L1, CAMSAP2, Calmodulin-regulated spectrin-associated protein 1-like protein 1, Calmodulin-regulated spectrin-associated protein 2, KIAA1078 |
| Background | Calmodulin-regulated spectrin-associated protein 2 is a ~168 kDa protein. Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In addition, it also reduces the velocity of microtubule polymerization. Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes. 1. Tanaka, N. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 20029-34. PMID: 23169647 2. Jiang, K. et al. (2014) Developmental cell 28, 295-309. PMID: 24486153 3. Hendershott, MC. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 5860-5. PMID: 24706919 4. Wu, J. et al. (2016) Developmental cell 39, 44-60. PMID: 27666745 6. Wei, J. et al. (2017) FEBS letters 591, 2379-2393. PMID: 28726242 |
| Note | For research use only |
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