Human CCDC25 Recombinant Protein (N-His) (HC767012)

Name: Human CCDC25 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC767012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC767012
Description	Recombinant Human CCDC25 Protein, N-His (HC767012) expressed in E. coli, spanning Met1-Phe141. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q86WR0
Protein length	Met1-Phe141
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	18.57 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CCDC25, Coiled-coil domain-containing protein 25
Background	Coiled-coil domain-containing protein 25 is a ~24 kDa protein. Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility. NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells. Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells. In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells. 1. Yang, L. et al. (2020) Nature 583, 133-138. PMID: 32528174
Note	For research use only

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Datasheet

Human CCDC25 Recombinant Protein (N-His).pdf

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Human CCDC25 Recombinant Protein (N-His) (HC767012)

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