Human CCDC88A Recombinant Protein (N-His) (HD272012)

Name: Human CCDC88A Recombinant Protein (N-His)
Brand: abinScience
SKU: HD272012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD272012
Description	Recombinant Human CCDC88A Protein, N-His (HD272012) expressed in E. coli, spanning Met1-Phe223. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q3V6T2
Protein length	Met1-Phe223
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	27.85 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	APE, Akt phosphorylation enhancer, CCDC88A, Coiled-coil domain-containing protein 88A, G alpha-interacting vesicle-associated protein, GIV, GRDN, Girders of actin filament, Girdin, HkRP1, Hook-related protein 1, KIAA1212
Background	Girdin is a ~216 kDa protein. Bifunctional modulator of guanine nucleotide-binding proteins (G proteins). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits. Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS. Essential for cell migration. Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration. 1. Garcia-Marcos, M. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 3178-83. PMID: 19211784 2. Gupta, V. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E5721-30. PMID: 27621449 3. Lin, C. et al. (2011) Science signaling 4, ra64. PMID: 21954290 4. López-Sánchez, I. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 5510-5. PMID: 23509302 5. Lin, C. et al. (2014) Molecular biology of the cell 25, 3654-71. PMID: 25187647 6. Enomoto, A. et al. (2005) Developmental cell 9, 389-402. PMID: 16139227 7. Ghosh, P. et al. (2010) Molecular biology of the cell 21, 2338-54. PMID: 20462955
Note	For research use only

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Datasheet

Human CCDC88A Recombinant Protein (N-His).pdf

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Human CCDC88A Recombinant Protein (N-His) (HD272012)

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