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Human CD135/FLT3 Recombinant Protein (N-GST & C-His) (HW794042)

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Overview

Catalog No.	HW794042
Description	Recombinant Human CD135/FLT3 Protein, N-GST & C-His (HW794042) expressed in E. coli, spanning Pro31-Tyr376. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P36888
Protein length	Pro31-Tyr376
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	67.18 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CD135, EC:2.7.10.1, FL cytokine receptor, FLK-2, FLK2, FLT-3, FLT3, Fetal liver kinase-2, Fms-like tyrosine kinase 3, Receptor-type tyrosine-protein kinase FLT3, STK-1, STK1, Stem cell tyrosine kinase 1
Background	Receptor-type tyrosine-protein kinase FLT3 is a ~112 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B.
Note	For research use only

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Datasheet

Human CD135/FLT3 Recombinant Protein (N-GST & C-His).pdf

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Human CD135/FLT3 Recombinant Protein (N-GST & C-His)