Human CD159c/KLRC2 Recombinant Protein (C-His) (HB713021)

Name: Human CD159c/KLRC2 Recombinant Protein (C-His)
Brand: abinScience
SKU: HB713021
Price: 298 USD
Availability: InStock

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Catalog No.	HB713021
Description	Recombinant Human CD159c/KLRC2 Protein, C-His (HB713021) expressed in Mammalian Cells, spanning Glu98-Leu231. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	P26717
Protein length	Glu98-Leu231
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	18.50 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	NKG2-C type II integral membrane protein, CD159 antigen-like family member C, NK cell receptor C, NKG2-C-activating NK receptor, CD159c, KLRC2, NKG2C
Background	NKG2-C type II integral membrane protein (CD159c/KLRC2) is a ~26 kDa protein. Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation. 1. Rölle, A. et al. (2018) Cell reports 24, 1967-1976.e4. PMID: 30134159 2. Lin, Z. et al. (2023) Nature immunology 24, 1087-1097. PMID: 37264229 3. Llano, M. et al. (1998) European journal of immunology 28, 2854-63. PMID: 9754572 4. Angelini, DF. et al. (2011) Journal of leukocyte biology 89, 75-84. PMID: 20952657 5. Lopez-Vergès, S. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 14725-32. PMID: 21825173 6. Gumá, M. et al. (2005) European journal of immunology 35, 2071-80. PMID: 15940674 7. Lanier, LL. et al. (1998) Immunity 8, 693-701. PMID: 9655483
Note	For research use only.

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SDS-PAGE for Recombinant Human CD159c/KLRC2 Protein, C-His

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Datasheet

Human CD159c/KLRC2 Recombinant Protein (C-His).pdf

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Human CD159c/KLRC2 Recombinant Protein (C-His) (HB713021)

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