Human CD367/CLEC4A Recombinant Protein (C-Fc) (HV145021)

Name: Human CD367/CLEC4A Recombinant Protein (C-Fc)
Brand: abinScience
SKU: HV145021
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	HV145021
Description	Recombinant Human CD367/CLEC4A Protein, C-Fc (HV145021) expressed in Mammalian Cells, spanning Gln70-Leu237. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	Q9UMR7
Protein length	Gln70-Leu237
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	48.19 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	C-type lectin DDB27, C-type lectin domain family 4 member A, C-type lectin superfamily member 6, CD367, CLEC4A, CLECSF6, DCIR, Dendritic cell immunoreceptor, LLIR, Lectin-like immunoreceptor
Background	C-type lectin domain family 4 member A is a ~27 kDa protein. C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. 1. Nagae, M. et al. (2016) FEBS letters 590, 1280-8. PMID: 27015765 2. Bates, EE. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1973-83. PMID: 10438934 3. Meyer-Wentrup, F. et al. (2008) Blood 111, 4245-53. PMID: 18258799 4. Klechevsky, E. et al. (2010) Blood 116, 1685-97. PMID: 20530286
Note	For research use only

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Datasheet

Human CD367/CLEC4A Recombinant Protein (C-Fc).pdf

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Human CD367/CLEC4A Recombinant Protein (C-Fc) (HV145021)

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