Human CORIN Recombinant Protein (N-GST) (HV019012)

Name: Human CORIN Recombinant Protein (N-GST)
Brand: abinScience
SKU: HV019012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HV019012
Description	Recombinant Human CORIN Protein, N-GST (HV019012) expressed in E. coli, spanning Gly70-Thr136. Purity: >90% by SDS-PAGE. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9Y5Q5
Protein length	Gly70-Thr136
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	34.05 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CORIN, CRN, Heart-specific serine proteinase ATC2, Corin, TMPRSS10, Pro-ANP-converting enzyme, Transmembrane protease serine 10, Atrial natriuretic peptide-converting enzyme
Background	Atrial natriuretic peptide-converting enzyme (CORIN) is a ~116 kDa protein. Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing. Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. 1. Yan, W. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 8525-9. PMID: 10880574 2. Semenov, AG. et al. (2010) Clinical chemistry 56, 1166-76. PMID: 20489134 3. Jiang, J. et al. (2011) The Journal of biological chemistry 286, 10066-72. PMID: 21288900 4. Peng, J. et al. (2011) Biochemical and biophysical research communications 411, 593-8. PMID: 21763278 5. Cui, Y. et al. (2012) Nature 484, 246-50. PMID: 22437503
Note	For research use only.

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SDS-PAGE for Recombinant Human CORIN Protein, N-GST

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Datasheet

Human CORIN Recombinant Protein (N-GST).pdf

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Formula

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Human CORIN Recombinant Protein (N-GST) (HV019012)

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