Human CPT1C Recombinant Protein (N-His) (HD953012)

Name: Human CPT1C Recombinant Protein (N-His)
Brand: abinScience
SKU: HD953012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD953012
Description	Recombinant Human CPT1C Protein, N-His (HD953012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q8TCG5
Protein length	Ser178-Gln790
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CATL1, CPT I-C, CPT1C, CPTI-B, Carnitine O-palmitoyltransferase 1, brain isoform, Carnitine palmitoyltransferase 1C, Carnitine palmitoyltransferase I, EC:3.1.2.22, Palmitoyl thioesterase CPT1C
Background	Palmitoyl thioesterase CPT1C is a ~90 kDa protein. Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1. Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner. Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control. Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels. 1. Gratacòs-Batlle, E. et al. (2018) Frontiers in molecular neuroscience 11, 275. PMID: 30135643 2. Wolfgang, MJ. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 7282-7. PMID: 16651524 3. Rinaldi, C. et al. (2015) JAMA neurology 72, 561-70. PMID: 25751282
Note	For research use only

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Datasheet

Human CPT1C Recombinant Protein (N-His).pdf

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Human CPT1C Recombinant Protein (N-His) (HD953012)

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