Human CYP2J2 Recombinant Protein (N-His) (HD745012)

Name: Human CYP2J2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD745012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD745012
Description	Recombinant Human CYP2J2 Protein, N-His (HD745012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P51589
Protein length	Gly54-Val502
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Albendazole monooxygenase (hydroxylating), Albendazole monooxygenase (sulfoxide-forming), Arachidonic acid epoxygenase, CYP2J2, CYPIIJ2, Cytochrome P450 2J2, EC:1.14.14.-, EC:1.14.14.73, EC:1.14.14.74, EC:5.4.4.7, Hydroperoxy icosatetraenoate isomerase
Background	Cytochrome P450 2J2 is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of PUFA. Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools. In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. 1. Lucas, D. et al. (2010) Journal of lipid research 51, 1125-33. PMID: 19965576 2. Wu, S. et al. (1996) The Journal of biological chemistry 271, 3460-8. PMID: 8631948 3. Chawengsub, Y. et al. (2009) The Journal of biological chemistry 284, 31280-90. PMID: 19737933 4. Lee, CA. et al. (2010) Drug metabolism and disposition: the biological fate of chemicals 38, 347-56. PMID: 19923256 5. Wu, Z. et al. (2013) Antimicrobial agents and chemotherapy 57, 5448-56. PMID: 23959307
Note	For research use only

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Datasheet

Human CYP2J2 Recombinant Protein (N-His).pdf

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Human CYP2J2 Recombinant Protein (N-His) (HD745012)

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