Human DDX39A Recombinant Protein (N-His) (HD747012)

Name: Human DDX39A Recombinant Protein (N-His)
Brand: abinScience
SKU: HD747012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD747012
Description	Recombinant Human DDX39A Protein, N-His (HD747012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	O00148
Protein length	Arg47-Arg427
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ATP-dependent RNA helicase DDX39A, DDX39, DDX39A, DEAD box protein 39, EC:3.6.4.13, Nuclear RNA helicase URH49
Background	ATP-dependent RNA helicase DDX39A is a ~49 kDa protein. Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing. Regulates nuclear mRNA export to the cytoplasm through association with ECD. Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX. Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression. Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA. 1. Saleem, I. et al. (2021) Molecular and cellular biology 41, e0010321. PMID: 33941617 2. Banerjee, S. et al. (2024) Nucleic acids research 52, 8534-8551. PMID: 38801080 3. Taniguchi, I. et al. (2024) Nucleic acids research 52, 10668-10682. PMID: 39011894 4. Shi, P. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 205, 168-180. PMID: 32393512 5. Tapescu, I. et al. (2023) Molecular cell 83, 4174-4189.e7. PMID: 37949067
Note	For research use only

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Datasheet

Human DDX39A Recombinant Protein (N-His).pdf

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Human DDX39A Recombinant Protein (N-His) (HD747012)

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