Human DGUOK Recombinant Protein (N-His) (HD865012)

Name: Human DGUOK Recombinant Protein (N-His)
Brand: abinScience
SKU: HD865012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD865012
Description	Recombinant Human DGUOK Protein, N-His (HD865012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q16854
Protein length	Arg40-Leu277
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	DGK, DGUOK, Deoxyadenosine kinase, mitochondrial, Deoxyguanosine kinase, mitochondrial, EC:2.7.1.113, EC:2.7.1.76
Background	Deoxyguanosine kinase, mitochondrial is a ~32 kDa protein. Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents. 1. Saada, A. et al. (2001) Nature genetics 29, 342-4. PMID: 11687801 2. Mousson de Camaret, B. et al. (2007) The Biochemical journal 402, 377-85. PMID: 17073823 3. Ronchi, D. et al. (2012) Brain : a journal of neurology 135, 3404-15. PMID: 23043144 4. Johansson, M. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 7258-62. PMID: 8692979 5. Wang, L. et al. (1996) FEBS letters 390, 39-43. PMID: 8706825
Note	For research use only

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Datasheet

Human DGUOK Recombinant Protein (N-His).pdf

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Human DGUOK Recombinant Protein (N-His) (HD865012)

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