Human FBXW11 Recombinant Protein (N-His) (HD950012)

Name: Human FBXW11 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD950012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD950012
Description	Recombinant Human FBXW11 Protein, N-His (HD950012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q9UKB1
Protein length	Arg227-Asn521
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	BTRCP2, F-box and WD repeats protein beta-TrCP2, F-box/WD repeat-containing protein 11, F-box/WD repeat-containing protein 1B, FBW1B, FBXW11, FBXW1B, HOS, Homologous to Slimb protein, KIAA0696
Background	F-box/WD repeat-containing protein 11 is a ~62 kDa protein. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation. SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription. The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation. 1. Vuillard, L. et al. (1999) FEBS letters 455, 311-4. PMID: 10437795 2. Wu, K. et al. (2000) Molecular and cellular biology 20, 1382-93. PMID: 10648623 3. Heissmeyer, V. et al. (2001) Molecular and cellular biology 21, 1024-35. PMID: 11158290 4. Peschiaroli, A. et al. (2010) Oncogene 29, 1384-93. PMID: 19966869 5. Wu, K. et al. (2010) Molecular cell 37, 784-96. PMID: 20347421 6. Gao, D. et al. (2011) Molecular cell 44, 290-303. PMID: 22017875 7. Zhao, Y. et al. (2011) Molecular cell 44, 304-16. PMID: 22017876 8. Nardone, C. et al. (2023) Molecular cell 83, 57-73.e9. PMID: 36608670 10. Suzuki, H. et al. (2000) The Journal of biological chemistry 275, 2877-84. PMID: 10644755
Note	For research use only

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Human FBXW11 Recombinant Protein (N-His).pdf

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Human FBXW11 Recombinant Protein (N-His) (HD950012)

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