Human GABRG2 Recombinant Protein (N-His) (HD751012)

Name: Human GABRG2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD751012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD751012
Description	Recombinant Human GABRG2 Protein, N-His (HD751012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P18507
Protein length	Thr90-Arg271
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	GABA(A) receptor subunit gamma-2, GABAAR subunit gamma-2, GABRG2, Gamma-aminobutyric acid receptor subunit gamma-2
Background	Gamma-aminobutyric acid receptor subunit gamma-2 is a ~55 kDa protein. Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. 1. Caraiscos, VB. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 3662-7. PMID: 14993607 2. Ranna, M. et al. (2006) BMC pharmacology 6, 1. PMID: 16412217 3. Fuchs, C. et al. (2013) The European journal of neuroscience 38, 3146-58. PMID: 23909897 4. Pritchett, DB. et al. (1989) Nature 338, 582-5. PMID: 2538761 5. Brown, LE. et al. (2014) Journal of visualized experiments : JoVE, e52115. PMID: 25489750 6. Shen, D. et al. (2017) Brain : a journal of neurology 140, 49-67. PMID: 27864268 7. Zhu, S. et al. (2018) Nature 559, 67-72. PMID: 29950725 8. Laverty, D. et al. (2019) Nature 565, 516-520. PMID: 30602789
Note	For research use only

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Datasheet

Human GABRG2 Recombinant Protein (N-His).pdf

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Human GABRG2 Recombinant Protein (N-His) (HD751012)

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