Human GDF-11/BMP-11 Recombinant Protein (N-His) (HF869032)

Name: Human GDF-11/BMP-11 Recombinant Protein (N-His)
Brand: abinScience
SKU: HF869032
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HF869032
Description	Recombinant Human GDF11/BMP11 Protein, N-His (HF869032) expressed in E. coli, spanning Asn299-Ser407. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O95390
Protein length	Asn299-Ser407
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	14.75 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	BMP-11, BMP11, Bone morphogenetic protein 11, GDF-11, GDF11, Growth/differentiation factor 11
Background	Growth/differentiation factor 11 is a ~45 kDa protein. Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3. 1. Cox, TC. et al. (2019) Human mutation 40, 1813-1825. PMID: 31215115 2. Walker, RG. et al. (2017) BMC biology 15, 19. PMID: 28257634
Note	For research use only