Human GGCX Recombinant Protein (N-His) (HD979012)

Name: Human GGCX Recombinant Protein (N-His)
Brand: abinScience
SKU: HD979012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD979012
Description	Recombinant Human GGCX Protein, N-His (HD979012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P38435
Protein length	Asn388-Gly709
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:4.1.1.90, GC, GGCX, Gamma-glutamyl carboxylase, Peptidyl-glutamate 4-carboxylase, VKGC, Vitamin K gamma glutamyl carboxylase, Vitamin K-dependent gamma-carboxylase
Background	Vitamin K-dependent gamma-carboxylase is a ~87 kDa protein. Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant epoxidation of vitamin K hydroquinone to vitamin K epoxide. Couples epoxidation and carboxylation in the same active site. Catalyzes gamma-carboxylation of blood coagulation factors (F2, F7, F9 and F10) and anticoagulants such as PROC, which are essential for thrombosis. Catalyzes gamma-carboxylation of osteocalcin/BGLAP, which is essential for bone metabolism. Catalyzes gamma-carboxylation of matrix Gla protein (MGP) and other transmembrane gamma-Gla proteins such as PRRG2, which are essential for calcium homeostasis and haemostasis. 1. Rishavy, MA. et al. (2006) Biochemistry 45, 13239-48. PMID: 17073445 2. Wang, R. et al. (2025) Nature 639, 808-815. PMID: 39880952 3. Cao, Q. et al. (2025) Nature 639, 816-824. PMID: 39880037
Note	For research use only

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Datasheet

Human GGCX Recombinant Protein (N-His).pdf

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Human GGCX Recombinant Protein (N-His) (HD979012)

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