Human GPR50 Recombinant Protein (N-His-KSI) (HD203012)

Name: Human GPR50 Recombinant Protein (N-His-KSI)
Brand: abinScience
SKU: HD203012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD203012
Description	Recombinant Human GPR50 Protein, N-His-KSI (HD203012) expressed in E. coli, spanning Gly295-Val617. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q13585
Protein length	Gly295-Val617
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	50.21 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	C-terminal domain, G protein-coupled receptor 50, GPR50, H9, Melatonin-related receptor
Background	Melatonin-related receptor is a ~67 kDa protein. G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration. Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways. Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalisation. Also plays a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration. 1. Grünewald, E. et al. (2009) Molecular and cellular neurosciences 42, 363-71. PMID: 19699797 2. Li, J. et al. (2011) PloS one 6, e23725. PMID: 21858214 3. Wojciech, S. et al. (2018) Nature communications 9, 1216. PMID: 29572483
Note	For research use only

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Datasheet

Human GPR50 Recombinant Protein (N-His-KSI).pdf

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Human GPR50 Recombinant Protein (N-His-KSI) (HD203012)

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