Human GPR84 Recombinant Protein (N-His) (HC793012)

Name: Human GPR84 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC793012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC793012
Description	Recombinant Human GPR84 Protein, N-His (HC793012) expressed in E. coli, spanning His202-Met320. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9NQS5
Protein length	His202-Met320
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	15.23 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EX33, G-protein coupled receptor 84, GPR84, Inflammation-related G-protein coupled receptor EX33
Background	G-protein coupled receptor 84 is a ~43 kDa protein. G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses through activation of signaling mediators AKT, ERK and NF-kappa-B. In addition, triggers increased bacterial adhesion and phagocytosis in macrophages and regulates pro-inflammatory function via enhancing NLRP3 inflammasome activation. Also plays an important role in inflammation by modulating neutrophil functions. 1. Wang, J. et al. (2006) The Journal of biological chemistry 281, 34457-64. PMID: 16966319 2. Mårtensson, J. et al. (2021) Journal of innate immunity 13, 242-256. PMID: 33789297
Note	For research use only

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Datasheet

Human GPR84 Recombinant Protein (N-His).pdf

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Human GPR84 Recombinant Protein (N-His) (HC793012)

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