Human GPRC6A Recombinant Protein (N-His) (HD873012)

Name: Human GPRC6A Recombinant Protein (N-His)
Brand: abinScience
SKU: HD873012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD873012
Description	Recombinant Human GPRC6A Protein, N-His (HD873012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q5T6X5
Protein length	Gln19-Ala594
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	G-protein coupled receptor GPCR33, G-protein coupled receptor family C group 6 member A, GPRC6A, hGPCR33, hGPRC6A
Background	G-protein coupled receptor family C group 6 member A is a ~104 kDa protein. Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations. Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. 1. Wellendorph, P. et al. (2005) Molecular pharmacology 67, 589-97. PMID: 15576628 2. Pi, M. et al. (2010) The Journal of biological chemistry 285, 39953-64. PMID: 20947496
Note	For research use only

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Datasheet

Human GPRC6A Recombinant Protein (N-His).pdf

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Human GPRC6A Recombinant Protein (N-His) (HD873012)

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