Human GRHL2 Recombinant Protein (N-His) (HD326012)

Name: Human GRHL2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD326012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD326012
Description	Recombinant Human GRHL2 Protein, N-His (HD326012) expressed in E. coli, spanning Gln274-Cys417. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q6ISB3
Protein length	Gln274-Cys417
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	19.20 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	BOM, Brother of mammalian grainyhead, GRHL2, Grainyhead-like protein 2 homolog, TFCP2L3, Transcription factor CP2-like 3
Background	Grainyhead-like protein 2 homolog is a ~71 kDa protein. Transcription factor playing an important role in primary neurulation and in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure. Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. 1. Petrof, G. et al. (2014) American journal of human genetics 95, 308-14. PMID: 25152456 2. Ming, Q. et al. (2018) Nucleic acids research 46, 2082-2095. PMID: 29309642 3. Kang, X. et al. (2009) Oncogene 28, 565-74. PMID: 19015635 4. Chen, W. et al. (2010) The Journal of biological chemistry 285, 40852-63. PMID: 20938050 5. Chen, W. et al. (2012) Cell death & disease 3, e450. PMID: 23254293
Note	For research use only

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Datasheet

Human GRHL2 Recombinant Protein (N-His).pdf

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Human GRHL2 Recombinant Protein (N-His) (HD326012)

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