Human GUK1 Recombinant Protein (N-His) (HD260012)

Name: Human GUK1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD260012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD260012
Description	Recombinant Human GUK1 Protein, N-His (HD260012) expressed in E. coli, spanning Met1-Ala197. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q16774
Protein length	Met1-Ala197
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	23.89 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:2.7.4.8, GMK, GMP kinase, GMPK, GUK1, Guanylate kinase, Guanylate kinase 1
Background	Guanylate kinase is a ~21 kDa protein. Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. It may also have a role in the survival and growth progression of some tumors. In addition to its physiological role, GUK1 is essential for converting prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine. 1. Khan, N. et al. (2019) The Journal of biological chemistry 294, 11920-11933. PMID: 31201273 2. Miller, RL. et al. (1977) Biochemical pharmacology 26, 1573-6. PMID: 197968 3. Miller, WH. et al. (1980) The Journal of biological chemistry 255, 7204-7. PMID: 6248551 4. Field, AK. et al. (1983) Proceedings of the National Academy of Sciences of the United States of America 80, 4139-43. PMID: 6306664
Note	For research use only

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Datasheet

Human GUK1 Recombinant Protein (N-His).pdf

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Human GUK1 Recombinant Protein (N-His) (HD260012)

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