Human HMBOX1 Recombinant Protein (N-His-SUMO) (HC247012)

Name: Human HMBOX1 Recombinant Protein (N-His-SUMO)
Brand: abinScience
SKU: HC247012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC247012
Description	Recombinant Human HMBOX1 Protein, N-His-SUMO (HC247012) expressed in E. coli, spanning Ser152-Thr235. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q6NT76
Protein length	Ser152-Thr235
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	22.07 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	HMBOX1, HOT1, Homeobox telomere-binding protein 1, Homeobox-containing protein 1, TAH1, Telomere-associated homeobox-containing protein 1
Background	Homeobox-containing protein 1 is a ~47 kDa protein. Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. 1. Kappei, D. et al. (2013) The EMBO journal 32, 1681-701. PMID: 23685356 2. Feng, X. et al. (2013) Journal of cell science 126, 3982-9. PMID: 23813958
Note	For research use only

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Datasheet

Human HMBOX1 Recombinant Protein (N-His-SUMO).pdf

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Human HMBOX1 Recombinant Protein (N-His-SUMO) (HC247012)

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