Human HSD17B3 Recombinant Protein (N-His) (HW736022)

Name: Human HSD17B3 Recombinant Protein (N-His)
Brand: abinScience
SKU: HW736022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HW736022
Description	Recombinant Human HSD17B3 Protein, N-His (HW736022) expressed in E. coli, spanning Ser42-Arg310. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P37058
Protein length	Ser42-Arg310
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	32.12 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	17-beta-HSD 3, 17-beta-hydroxysteroid dehydrogenase type 3, EC:1.1.1.62, EC:1.1.1.64, EDH17B3, Estradiol 17-beta-dehydrogenase 2, HSD17B3, SDR12C2, Short chain dehydrogenase/reductase family 12C member 2, Testicular 17-beta-hydroxysteroid dehydrogenase, Testosterone 17-beta-dehydrogenase 3
Background	17-beta-hydroxysteroid dehydrogenase type 3 is a ~34 kDa protein. Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids. Favors the reduction of androstenedione to testosterone. Testosterone is the key androgen driving male development and function. Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. 1. Mindnich, R. et al. (2005) Journal of molecular endocrinology 35, 305-16. PMID: 16216911 2. Engeli, RT. et al. (2016) The Journal of steroid biochemistry and molecular biology 155, 147-54. PMID: 26545797 3. Tsachaki, M. et al. (2017) The Journal of endocrinology 232, 323-335. PMID: 27927697 4. Geissler, WM. et al. (1994) Nature genetics 7, 34-9. PMID: 8075637
Note	For research use only

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Datasheet

Human HSD17B3 Recombinant Protein (N-His).pdf

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Human HSD17B3 Recombinant Protein (N-His) (HW736022)

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