Human IFITM3 Recombinant Protein (N-His-SUMO & C-Strep) (HD912012)

Name: Human IFITM3 Recombinant Protein (N-His-SUMO & C-Strep)
Brand: abinScience
SKU: HD912012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD912012
Description	Recombinant Human IFITM3 Protein, N-His-SUMO & C-Strep (HD912012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q01628
Protein length	Asp56-Gly133
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	DSPA2b, Dispanin subfamily A member 2b, IFITM3, Interferon-induced transmembrane protein 3, Interferon-inducible protein 1-8U
Background	Interferon-induced transmembrane protein 3 is a ~14 kDa protein. IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry. 1. Narayana, SK. et al. (2015) The Journal of biological chemistry 290, 25946-59. PMID: 26354436 2. Zang, R. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 32105-32113. PMID: 33239446 3. Shi, G. et al. (2021) The EMBO journal 40, e106501. PMID: 33270927
Note	For research use only

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Datasheet

Human IFITM3 Recombinant Protein (N-His-SUMO & C-Strep).pdf

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Human IFITM3 Recombinant Protein (N-His-SUMO & C-Strep) (HD912012)

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Datasheet

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